tag:blogger.com,1999:blog-1527840491496268397.post5926954899447522973..comments2024-03-08T11:20:30.095-07:00Comments on Credit Bubble Stocks: Monday Night LinksUnknownnoreply@blogger.comBlogger2125tag:blogger.com,1999:blog-1527840491496268397.post-43992663054400644972023-01-23T18:59:14.023-07:002023-01-23T18:59:14.023-07:00Increased occurrence in clinical practice and scie...<i>Increased occurrence in clinical practice and scientific reports in the literature suggest that the phosphodiesterase type 5 inhibitors are considered a risk factor for sudden deafness. Further studies with larger samples and control groups are needed for better assessing this association.</i><br /><br />https://www.sciencedirect.com/science/article/pii/S1808869415302238CPhttps://www.blogger.com/profile/12701174164478027499noreply@blogger.comtag:blogger.com,1999:blog-1527840491496268397.post-90325779637375026662023-01-23T16:50:07.869-07:002023-01-23T16:50:07.869-07:00That PDE5 study seems legit. Huge sample size. Con...That PDE5 study seems legit. Huge sample size. Controls have ED, just didn't fill an Rx for a PDE5i. I reckon there's truth to men filling Rx's were in better relationships, so that's probably something too. Would/could it account for entirety of effect size? Not sure.<br /><br /><i>* exposure to PDE-5is was associated with significant and clinically meaningful lower incidence of MACE (by 13%), total mortality (by 25%) and CV mortality (by 39%)</i><br /><br />25% reduction in all-cause mortality seems like a lot. Could you get that from just being happily married? Not sure.<br /><br />39% reduction in CV mortality is definitely a lot. Could you get that from just being happily married? I'm doubtful. Seems way too much.<br /><br /><i>* men with the highest quartile of PDE-5i exposure had correspondingly greater reductions in MACE (by 55%) and overall mortality (by 49%) compared to the lowest quartile of PDE-5i use.</i><br /><br />Dose-response is positive, which is important to see when evaluating whether studies like this have any value.<br /><br /><br />We really need to disentangle if causality is the PDE5 inhibition or general vasodilation, which is equivalent to extra NOx from L-citrulline. It occurred to me nitroglycerin tabs work similarly as L-cit for putting NOx into the bloodstream. OTOH, you gotta be pretty sick to get a nitroglycerin Rx. Would be hard to extrapolate anything meaningful with that hanging all over the data.Allan Folzhttps://www.blogger.com/profile/06762674627739423845noreply@blogger.com